Article
Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer.
Cancer research - 15 Dec 2017
Goldstein Jonathan T, Berger Ashton C, Shih Juliann, Duke Fujiko F, Furst Laura, Kwiatkowski David J, Cherniack Andrew D, Meyerson Matthew, Strathdee Craig A
Abstract excerpt
The PPARG gene encoding the nuclear receptor PPARγ is activated in bladder cancer, either directly by gene amplification or mutation, or indirectly by mutation of the RXRA gene, which encodes the heterodimeric partner of PPARγ. Here, we show that activating alterations of PPARG or RXRA lead to a specific gene expression signature in bladder cancers. Reducing PPARG activity, whether by pharmacologic inhibition or...
Topics
- Animals
- CRISPR-Cas Systems
- Cell Line, Tumor
- Gene Amplification
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Microarray Analysis
- Molecular Targeted Therapy
- Mutation
- PPAR gamma
- Transcriptome
- Urinary Bladder Neoplasms