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Article

PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).

Cancer causes & control : CCC - 1 Apr 2006

Slattery Martha L, Curtin Karen, Wolff Roger, Ma Khe Ni, Sweeney Carol, Murtaugh Maureen, Potter John D, Levin Theodore R, Samowitz Wade

Abstract excerpt

We hypothesize that the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with colorectal cancer given its association with insulin, diabetes, obesity, and inflammation. In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. We also evaluated interactions between the PPARgamma gene and other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16489531
DOI: 10.1007/s10552-005-0411-6

Genes

IGFBP3
VDR
IGF1
IRS1
IRS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).PMID 16489531Read ↗

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Diet and PPARG2 Pro12Ala Polymorphism Interactions in Relation to Cancer Risk: A Systematic Review.Semantic proximity Read ↗

Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk.Semantic proximity Read ↗

Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway.Semantic proximity Read ↗

PPARgamma polymorphisms and cancer risk: a meta-analysis involving 32,138 subjects.Semantic proximity Read ↗

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