Article
Human IgA activates the complement system via the mannan-binding lectin pathway.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2001
Roos A, Bouwman L H, van Gijlswijk-Janssen D J, Faber-Krol M C, Stahl G L, Daha M R
Abstract excerpt
The recently identified lectin pathway of the complement system, initiated by binding of mannan-binding lectin (MBL) to its ligands, is a key component of innate immunity. MBL-deficient individuals show an increased susceptibility for infections, especially of the mucosal system. We examined whether IgA, an important mediator of mucosal immunity, activates the complement system via the lectin pathway. Our results...
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