Article
Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis.
Immunological reviews - 1 Apr 2001
Jack D L, Klein N J, Turner M W
Abstract excerpt
Mannose-binding lectin (MBL) is an important constituent of the innate immune system. This protein binds through multiple lectin domains to the repeating sugar arrays that decorate many microbial surfaces, and is then able to activate the complement system through a specific protease called MBL-associated protease-2. We have used flow cytometry to study both the binding of MBL to microorganisms and the subsequent...
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