Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of the lectin pathway of complement in human serum.

Molecular immunology - 1 Jan 2003

Roos Anja, Bouwman Lee H, Munoz Jeric, Zuiverloon Tahlita, Faber-Krol Maria C, Fallaux-van den Houten Francien C, Klar-Mohamad Ngaisah, Hack C Erik, Tilanus Marcel G, Daha Mohamed R

Abstract excerpt

Mannan-binding lectin (MBL) is a major initiator of the lectin pathway (LP) of complement. Polymorphisms in exon 1 of the MBL gene are associated with impaired MBL function and infections. Functional assays to assess the activity of the classical pathway (CP) and the alternative pathway (AP) of complement in serum are broadly used in patient diagnostics. We have now developed a functional LP assay that enables...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Complement C1q

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Pathway, Alternative

Share to Complement System Proteins

Share to Enzyme-Linked Immunosorbent Assay

Share to Mannans

Share to Mannose-Binding Lectin

Share to Mutation

Source

Identifiers

PMID: 12493641
DOI: 10.1016/s0161-5890(02)00254-7

Genes

NHS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of the lectin pathway of complement in human serum.PMID 12493641Read ↗

Mannan-binding lectin and its role in innate immunity.Semantic proximity Read ↗

Analysis of the relationship between mannose-binding lectin (MBL) genotype, MBL levels and function in an Australian blood donor population.Semantic proximity Read ↗

Mannan-binding lectin deficiency - Good news, bad news, doesn't matter?Semantic proximity Read ↗

Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis.Semantic proximity Read ↗

The mannose-binding lectin: a prototypic pattern recognition molecule.Semantic proximity Read ↗

Heteroligomeric forms of codon 54 mannose binding lectin (MBL) in circulation demonstrate reduced in vitro function.Semantic proximity Read ↗

Mannose-binding lectin: structure, function, genetics and disease associations.Semantic proximity Read ↗

MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement.Semantic proximity Read ↗

Mannan-binding lectin--a soluble pattern recognition molecule.Semantic proximity Read ↗

Mannan-binding lectin: clinical significance and applications.Semantic proximity Read ↗

The role of mannose-binding lectin in health and disease.Semantic proximity Read ↗

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.