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Article

Nomenclature for alleles of the thiopurine methyltransferase gene.

Pharmacogenetics and genomics - 1 Apr 2013

Appell Malin L, Berg Jonathan, Duley John, Evans William E, Kennedy Martin A, Lennard Lynne, Marinaki Tony, McLeod Howard L, Relling Mary V, Schaeffeler Elke, Schwab Matthias, Weinshilboum Richard, Yeoh Allen E J, McDonagh Ellen M, Hebert Joan M, Klein Teri E, Coulthard Sally A

Abstract excerpt

The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice. TPMT metabolizes the thiopurines 6-mercaptopurine, 6-thioguanine, and azathioprine, drugs that are widely used for treatment of acute leukemias, inflammatory bowel diseases, and other disorders of immune regulation. Since the discovery of genetic...

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Identifiers

PMID: 23407052
DOI: 10.1097/FPC.0b013e32835f1cc0
PMCID: PMC3727893

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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