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Article

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis.

Clinical pharmacology and therapeutics - 1 Aug 2000

Yan L, Zhang S, Eiff B, Szumlanski C L, Powers M, O'Brien J F, Weinshilboum R M

Abstract excerpt

BACKGROUND: Thiopurine methyltransferase (TPMT) is a genetically polymorphic enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Recently, a variable number tandem repeat (VNTR) within the TPMT promoter has been reported to "modulate" levels of this enzyme activity. METHODS: We set out to perform genotype-phenotype correlation analysis for the polymorphic TPMT tandem repeat in...

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Identifiers

PMID: 10976552
DOI: 10.1067/mcp.2000.108674

Genes

TPMT

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