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Article

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

British journal of pharmacology - 1 Oct 1998

Spire-Vayron de la Moureyre C, Debuysere H, Mastain B, Vinner E, Marez D, Lo Guidice J M, Chevalier D, Brique S, Motte K, Colombel J F, Turck D, Noel C, Flipo R M, Pol A, Lhermitte M, Lafitte J J, Libersa C, Broly F

Abstract excerpt

1. Characterization of allelic variants of the TPMT gene (TPMT) responsible for changes in TPMT activity, and elucidation of the mechanism by which these alleles act, are required because of the clinical importance of this polymorphism for patients receiving thiopurine drugs. 2. We defined the mu...

Topics

Alleles
Europe
Gene Frequency
Genotype
Humans
Methyltransferases
Minisatellite Repeats
Mutation
Phenotype
Polymorphism, Genetic
Purines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 9831928
DOI: 10.1038/sj.bjp.0702152
PMCID: PMC1571045

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9831928-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.PMID 9831928Read ↗

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