Article
Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.
British journal of pharmacology - 1 Oct 1998
Spire-Vayron de la Moureyre C, Debuysere H, Mastain B, Vinner E, Marez D, Lo Guidice J M, Chevalier D, Brique S, Motte K, Colombel J F, Turck D, Noel C, Flipo R M, Pol A, Lhermitte M, Lafitte J J, Libersa C, Broly F
Abstract excerpt
1. Characterization of allelic variants of the TPMT gene (TPMT) responsible for changes in TPMT activity, and elucidation of the mechanism by which these alleles act, are required because of the clinical importance of this polymorphism for patients receiving thiopurine drugs. 2. We defined the mutational and allelic spectrum of TPMT in a group of 191 Europeans. Using PCR-SSCP, we screened for mutation the entire...
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