Article
The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.
European journal of immunology - 1 Aug 2001
Byrd-Leifer C A, Block E F, Takeda K, Akira S, Ding A
Abstract excerpt
Taxol can mimic bacterial lipopolysaccharide (LPS) by activating mouse macrophages in a cell cycle-independent, LPS antagonist-inhibitable manner. Macrophages from C3H/HeJ mice, which have a spontaneous mutation in Toll-like receptor 4 (TLR4), are hyporesponsive to both LPS and Taxol, suggesting that LPS and Taxol may share a signaling pathway involving TLR4. To determine whether TLR4 and its interacting adaptor...
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