Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2001

Means T K, Jones B W, Schromm A B, Shurtleff B A, Smith J A, Keane J, Golenbock D T, Vogel S N, Fenton M J

Abstract excerpt

We previously showed that viable Mycobacterium tuberculosis (Mtb) bacilli contain distinct ligands that activate cells via the mammalian Toll-like receptor (TLR) proteins TLR2 and TLR4. We now demonstrate that expression of a dominant negative TLR2 or TLR4 proteins in RAW 264.7 macrophages partia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Lipid A
Share to Macrophages, Alveolar

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesocricetus

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type II

Share to Toll-Like Receptor 2

Share to Toll-Like Receptors

Source

Identifiers

PMID: 11238656
DOI: 10.4049/jimmunol.166.6.4074

Genes

TLR4
TNF
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11238656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.PMID 11238656Read ↗

Impaired expression of Toll-like receptor 2 in nontuberculous mycobacterial lung disease.Semantic proximity Read ↗

The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.Semantic proximity Read ↗

Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice.Semantic proximity Read ↗

What is the Role of Nitric Oxide in Murine and Human Host Defense against Tuberculosis?Semantic proximity Read ↗

Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2.Semantic proximity Read ↗

Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner.Semantic proximity Read ↗

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.Semantic proximity Read ↗

MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.