Article
Lipopolysaccharide induction of MARCKS-related protein and cytokine secretion are differentially impaired in microglia from LPS-nonresponsive (C3H/HeJ) mice.
Neurochemical research - 1 Dec 1998
Byers D M, Rosé S D, Cook H W, Hao C, Fedoroff S
Abstract excerpt
Many events involved in activation of microglia and leukocytes by lipopolysaccharide (LPS) are mediated by protein kinase C (PKC), and we have recently demonstrated that a major PKC substrate, MARCKS-related protein (MRP), is selectively induced by LPS in murine microglia. In microglia from LPS-n...
Topics
- Animals
- Blotting, Western
- Calmodulin-Binding Proteins
- Cells, Cultured
- Colony-Stimulating Factors
- Cytokines
- Electrophoresis, Polyacrylamide Gel
- Intracellular Signaling Peptides and Proteins
- Lipopolysaccharides
- Membrane Proteins
- Mice
- Mice, Inbred Strains
- Microfilament Proteins
- Microglia