Article
Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2002
Abel Brian, Thieblemont Nathalie, Quesniaux Valerie J F, Brown Najmeeyah, Mpagi Joseph, Miyake Kensuke, Bihl Franck, Ryffel Bernhard
Abstract excerpt
Endotoxin from Gram-negative bacteria bound to CD14 signals through Toll-like receptor (TLR) 4, while components of Gram-positive bacteria, fungi, and Mycobacterium tuberculosis (M.tb.) preferentially use TLR2 signaling. We asked whether TLR4 plays any role in host resistance to M.tb. infection in vivo. Therefore, we infected the TLR4 mutant C3H/HeJ mice and their controls, C3H/HeN mice, with M.tb. by aerosol....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.