Nuclease activity of the MutS homologue MutS2 from Thermus thermophilus is confined to the Smr domain.

doi:10.1093/nar/gkl735

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Article

Nuclease activity of the MutS homologue MutS2 from Thermus thermophilus is confined to the Smr domain.

Nucleic acids research - 1 Jan 2007

Fukui Kenji, Kosaka Hiromichi, Kuramitsu Seiki, Masui Ryoji

Abstract excerpt

MutS homologues are highly conserved enzymes engaged in DNA mismatch repair (MMR), meiotic recombination and other DNA modifications. Genome sequencing projects have revealed that bacteria and plants possess a MutS homologue, MutS2. MutS2 lacks the mismatch-recognition domain of MutS, but contains an extra C-terminal region called the small MutS-related (Smr) domain. Sequences homologous to the Smr domain are...

Topics

Adenosine Triphosphatases
Bacterial Proteins
DNA
Dimerization
Endodeoxyribonucleases
MutS Homolog 2 Protein
Mutation
Protein Structure, Tertiary
Thermus thermophilus

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Identifiers

PMID: 17215294
DOI: 10.1093/nar/gkl735
PMCID: PMC1807967

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