Article
Nuclease activity of the MutS homologue MutS2 from Thermus thermophilus is confined to the Smr domain.
Nucleic acids research - 1 Jan 2007
Fukui Kenji, Kosaka Hiromichi, Kuramitsu Seiki, Masui Ryoji
Abstract excerpt
MutS homologues are highly conserved enzymes engaged in DNA mismatch repair (MMR), meiotic recombination and other DNA modifications. Genome sequencing projects have revealed that bacteria and plants possess a MutS homologue, MutS2. MutS2 lacks the mismatch-recognition domain of MutS, but contains an extra C-terminal region called the small MutS-related (Smr) domain. Sequences homologous to the Smr domain are...
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