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Article

Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.

Molecular biology of the cell - 1 Feb 2006

Lévesque Lyne, Bor Yeou-Cherng, Matzat Leah H, Jin Li, Berberoglu Stephen, Rekosh David, Hammarskjöld Marie-Louise, Paschal Bryce M

Abstract excerpt

Interactions between transport receptors and phenylalanine-glycine (FG) repeats on nucleoporins drive the translocation of receptor-cargo complexes through nuclear pores. Tap, a transport receptor that mediates nuclear export of cellular mRNAs, contains a UBA-like and NTF2-like folds that can associate directly with FG repeats. In addition, two nuclear export sequences (NESs) within the NTF2-like region can also...

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Identifiers

PMID: 16314397
DOI: 10.1091/mbc.e04-07-0634
PMCID: PMC1356601

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Source receipt: pubmed, retrieved 7 Sept 2026.

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