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Article

A role for the divergent actin gene, ACT2, in nuclear pore structure and function.

The EMBO journal - 16 Jun 1997

Yan C, Leibowitz N, Mélèse T

Abstract excerpt

We have identified a temperature-sensitive allele of the yeast divergent actin gene ACT2, act2-1, which displays defects in nuclear pore complex (NPC) structure and nuclear import at the restrictive temperature. Although defective in nuclear import, act2-1 cells still selectively retain reporter proteins in the nucleus, and by indirect immunofluorescence the actin cytoskeleton appears normal. Previous studies in...

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Identifiers

PMID: 9218799
DOI: 10.1093/emboj/16.12.3572
PMCID: PMC1169982

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