Article
Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.
Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009
Napetschnig Johanna, Kassube Susanne A, Debler Erik W, Wong Richard W, Blobel Günter, Hoelz André
Abstract excerpt
Key steps in the export of mRNA from the nucleus to the cytoplasm are the transport through the nuclear pore complex (NPC) and the subsequent remodeling of messenger RNA-protein (mRNP) complexes that occurs at the cytoplasmic side of the NPC. Crucial for these events is the recruitment of the DEAD-box helicase Ddx19 to the cytoplasmic filaments of the NPC that is mediated by the nucleoporin Nup214. Here, we...
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