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Article

Two distinct nodes of translational inhibition in the Integrated Stress Response

30 Nov 2017

Abstract excerpt

The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understand how stressed cells coordinate gene expression at translational and transcriptional levels. The...

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PMID: 28803610
DOI: 10.5483/bmbrep.2017.50.11.157

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