Article

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition

2021-03-24

Abstract excerpt

<title>Abstract</title> <p>The endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) helps decide cell survival in diabetes. The alternative eukaryotic initiation factor 2A (EIF2A) has been proposed to mediate EIF2S1-independent translation during cellular stress and viral infection, but its role in cells is unknown. EIF2A abundance is high in human and mouse islets relative to other tissues,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68a74c1a-aa55-5087-a9da-1c92825149ac
DOI: 10.21203/rs.3.rs-343655/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibitionDOI 10.21203/rs.3.rs-343655/v1Read

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibitionSemantic proximity Read

Regulated translation initiation controls stress-induced gene expression in mammalian cells.Semantic proximity Read

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.Semantic proximity Read

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.Semantic proximity Read

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetesSemantic proximity Read

MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosisSemantic proximity Read

Thapsigargin and Tunicamycin Block SARS-CoV-2 Entry into Host Cells via Differential Modulation of Unfolded Protein Response (UPR), AKT Signaling, and ApoptosisSemantic proximity Read

Unfolded proteins in the mitochondria activate HRI and shut-down of mitochondrial protein translationSemantic proximity Read

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.Semantic proximity Read

Role of the Unfolded Protein Response in<i>β</i>Cell Compensation and Failure during DiabetesSemantic proximity Read

The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I Interferon ProductionSemantic proximity Read

The stress-induced protein NUPR1 orchestrates protein translation during ER-stress by interacting with eIF2αSemantic proximity Read