Article
Two polymorphic variants of wild-type p53 differ biochemically and biologically.
Molecular and cellular biology - 1 Feb 1999
Thomas M, Kalita A, Labrecque S, Pim D, Banks L, Matlashewski G
Abstract excerpt
The wild-type p53 protein exhibits a common polymorphism at amino acid 72, resulting in either a proline residue (p53Pro) or an arginine residue (p53Arg) at this position. Despite the difference that this change makes in the primary structure of the protein resulting in a difference in migration during sodium dodecyl sulfate-polyacrylamide gel electrophoresis, no differences in the biochemical or biological...
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