Article
Alteration of a p53 gene status affects outcome of patients with recurrent ovarian cancer.
Oncology - 1 Apr 2000
Irie T, Kigawa J, Minagawa Y, Oishi T, Takahashi M, Shimada M, Kamazawa S, Sato S, Terakawa N
Abstract excerpt
The aim of this longitudinal study was to examine whether and how the p53 gene is altered in patients with recurrent ovarian cancer and to determine the significance of p53 mutation in recurrent tumors. The primary and recurrent tumors were examined in 15 patients who had recurrent epithelial ovarian cancer, and whose primary tumor contained a wild-type p53 gene. The interval between cytoreductive surgery and the...
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