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Article

mDia mediates Rho-regulated formation and orientation of stable microtubules.

Nature cell biology - 1 Aug 2001

Palazzo A F, Cook T A, Alberts A S, Gundersen G G

Abstract excerpt

Rho-GTPase stabilizes microtubules that are oriented towards the leading edge in serum-starved 3T3 fibroblasts through an unknown mechanism. We used a Rho-effector domain screen to identify mDia as a downstream Rho effector involved in microtubule stabilization. Constitutively active mDia or activation of endogenous mDia with the mDia-autoinhibitory domain stimulated the formation of stable microtubules that were...

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Identifiers

PMID: 11483957
DOI: 10.1038/35087035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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