Article
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1.
Nature cell biology - 1 Jan 2001
Ishizaki T, Morishima Y, Okamoto M, Furuyashiki T, Kato T, Narumiya S
Abstract excerpt
Coordination of microtubules and the actin cytoskeleton is important in several types of cell movement. mDia1 is a member of the formin-homology family of proteins and an effector of the small GTPase Rho. It contains the Rho-binding domain in its amino terminus and two distinct regions of formin homology, FH1 in the middle and FH2 in the carboxy terminus. Here we show that expression of mDia1(DeltaN3), an active...
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