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Article

Glioblastoma motility occurs in the absence of actin polymer.

Molecular biology of the cell - 1 Jul 2011

Panopoulos Andreas, Howell Michael, Fotedar Rati, Margolis Robert L

Abstract excerpt

In fibroblasts and keratocytes, motility is actin dependent, while microtubules play a secondary role, providing directional guidance. We demonstrate here that the motility of glioblastoma cells is exceptional, in that it occurs in cells depleted of assembled actin. Cells display persistent motility in the presence of actin inhibitors at concentrations sufficient to fully disassemble actin. Such actin independent...

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Identifiers

PMID: 21551075
DOI: 10.1091/mbc.E10-10-0849
PMCID: PMC3128524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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