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Article

The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.

Journal of cell science - 15 May 2017

Breznau Elaina B, Murt Megan, Blasius T Lynne, Verhey Kristen J, Miller Ann L

Abstract excerpt

Centralspindlin, a complex of the kinesin-6-family member MKLP1 and MgcRacGAP (also known as Kif23 and Racgap1, respectively), is required for cytokinesis and cell-cell junctions. During anaphase, Centralspindlin accumulates at overlapping central spindle microtubules and directs contractile ring formation by recruiting the GEF Ect2 to the cell equator to activate RhoA. We found that MgcRacGAP localized to the...

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Identifiers

PMID: 28389580
DOI: 10.1242/jcs.195891
PMCID: PMC5450188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.PMID 28389580Read ↗

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