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Article

Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.

The Journal of biological chemistry - 15 Apr 2011

Goh Wah Ing, Sudhaharan Thankiah, Lim Kim Buay, Sem Kai Ping, Lau Chew Ling, Ahmed Sohail

Abstract excerpt

Filopodia are cellular protrusions important for axon guidance, embryonic development, and wound healing. The Rho GTPase Cdc42 is the best studied inducer of filopodium formation, and several of its effectors and their interacting partners have been linked to the process. These include IRSp53, N-WASP, Mena, and Eps8. The Rho GTPase, Rif, also drives filopodium formation. The signaling pathway by which Rif induces...

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Identifiers

PMID: 21339294
DOI: 10.1074/jbc.M110.182683
PMCID: PMC3075712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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