Article
Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients.
International journal of radiation oncology, biology, physics - 1 Aug 2001
Severin D M, Leong T, Cassidy B, Elsaleh H, Peters L, Venter D, Southey M, McKay M
Abstract excerpt
PURPOSE: Radiation therapy is an important treatment modality for oncology patients. DNA sequence variants have so far been identified in only a few genes in radiosensitive cancer patients. Patients known to be clinically radiosensitive were tested for mutation of a gene involved in DNA double-strand break repair and sister chromatid cohesion--hHR21. METHODS AND MATERIALS: Clinically radiation-sensitive patients...
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