Article
Analysis of tumor cell evolution in a melanoma: evidence of mutational and selective pressure for loss of p16ink4 and for microsatellite instability.
The Journal of investigative dermatology - 1 Jan 2000
Rübben A, Babilas P, Baron J M, Hofheinz A, Neis M, Sels F, Sporkert M
Abstract excerpt
Tumorigenesis and tumor progression can be considered an evolutionary process. In order to deduce information on the mutational and selective pressures during melanoma progression we performed microsatellite analysis at 42 autosomal and two X-linked loci in a microdissected primary melanoma and i...
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