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Article

Analysis of tumor cell evolution in a melanoma: evidence of mutational and selective pressure for loss of p16ink4 and for microsatellite instability.

The Journal of investigative dermatology - 1 Jan 2000

Rübben A, Babilas P, Baron J M, Hofheinz A, Neis M, Sels F, Sporkert M

Abstract excerpt

Tumorigenesis and tumor progression can be considered an evolutionary process. In order to deduce information on the mutational and selective pressures during melanoma progression we performed microsatellite analysis at 42 autosomal and two X-linked loci in a microdissected primary melanoma and its nine metastases. Loss of heterozygosity at locus D9S259 was the only genetic change observed in all metastases. The...

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Source

Identifiers

PMID: 10620109
DOI: 10.1046/j.1523-1747.2000.00838.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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