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Article

Class I beta-tubulin mutations in 2-methoxyestradiol-resistant acute lymphoblastic leukemia cells: implications for drug-target interactions.

Molecular cancer therapeutics - 1 Oct 2008

Liaw Tracy Y E, Salam Noeris K, McKay Matthew J, Cunningham Anne M, Hibbs David E, Kavallaris Maria

Abstract excerpt

2-Methoxyestradiol (2ME2) is a naturally occurring derivative of estradiol that has been shown to be an active small molecule that has antitumor and antiangiogenic properties. 2ME2 binds to beta-tubulin near the colchicine-binding site, inhibits microtubule polymerization, and induces mitotic arrest. To improve understanding of the mechanisms of action and resistance to 2ME2, we selected leukemia cells, CCRF-CEM,...

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Identifiers

PMID: 18852118
DOI: 10.1158/1535-7163.MCT-08-0442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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