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Article

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions.

Chemistry & biology - 1 Jul 2003

Verrills Nicole M, Flemming Claudia L, Liu Marjorie, Ivery Michael T, Cobon Gary S, Norris Murray D, Haber Michelle, Kavallaris Maria

Abstract excerpt

Epothilones, like paclitaxel, bind to beta-tubulin and stabilize microtubules. We selected a series of four leukemia sublines that display increasing levels of resistance to the epothilone analog desoxyepothilone B (dEpoB). The dEpoB cells selected in 30-140 nM were approximately 15-fold cross-resistant to paclitaxel, while 300 nM selected cells were 467-fold resistant to this agent. The dEpoB-selected cells are...

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PMID: 12890533
DOI: 10.1016/s1074-5521(03)00141-8

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MAP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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