Microtubule alterations and resistance to tubulin-binding agents (Review)

Abstract excerpt

Antimitotic agents that bind to tubulin and disrupt microtubule dynamics, such as vinca alkaloids and taxanes, are an integral part of the treatment of many human cancers. Unfortunately the clinical success of these agents can be severely hindered by the emergence of drug resistant tumour cells. In recent years interest has focused on alterations in the cellular target of antimicrotubule compounds, the tubulin/...

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