Article
A geometric and algebraic view of MHC-peptide complexes and their binding properties.
BMC structural biology - 1 Jan 2001
Cano P, Fan B
Abstract excerpt
BACKGROUND: Major histocompatibility complex (MHC) molecules present peptides to T lymphocytes. It is of critical biological and medical importance to elucidate how different MHC alleles bind to a specific set of peptides. METHOD: In this study we approach the problem from the algebraic and geometric point of view to analyse MHC-peptide-binding data accumulated over the years. The space of sequence properties...
Topics
- Alleles
- Amino Acid Motifs
- Amino Acids
- HLA Antigens
- Histocompatibility Antigens Class I
- Humans
- Macromolecular Substances
- Models, Theoretical
- Molecular Structure
- Peptides
- Polymorphism, Genetic
- Protein Binding