Article
Integrating peptides' sequence and energy of contact residues information improves prediction of peptide and HLA-I binding with unknown alleles.
BMC bioinformatics - 1 Jan 2013
Luo Fei, Gao Yangyang, Zhu Yongqiong, Liu Juan
Abstract excerpt
BACKGROUND: The HLA (human leukocyte antigen) class I is a kind of molecule encoded by a large family of genes and is characteristic of high polymorphism. Now the number of the registered HLA-I molecules has exceeded 3000. Slight differences in the amino acid sequences of HLAs would make them bind to different sets of peptides. In the past decades, although many methods have been proposed to predict the binding...
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