Article
Identifying HLA supertypes by learning distance functions.
Bioinformatics (Oxford, England) - 15 Jan 2007
Hertz Tomer, Yanover Chen
Abstract excerpt
MOTIVATION: The development of epitope-based vaccines crucially relies on the ability to classify Human Leukocyte Antigen (HLA) molecules into sets that have similar peptide binding specificities, termed supertypes. In their seminal work, Sette and Sidney defined nine HLA class I supertypes and claimed that these provide an almost perfect coverage of the entire repertoire of HLA class I molecules. HLA alleles are...
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