Article
Mycophenolic acid interferes the transcriptional regulation and protein trafficking of maturation surface markers in dendritic cells.
International immunopharmacology - 1 Feb 2021
Fontova Pere, Rama Inés, Llaudó Inés, Vidal-Alabró Anna, Cerezo Gema, Manzano Anna, Bestard Oriol, Cruzado Josep M, Torras Joan, Grinyó Josep M, Lloberas Núria
Abstract excerpt
BACKGROUND: The ability of dendritic cells (DCs) to regulate adaptive immunity makes them interesting cells to be used as therapeutic targets modulating alloimmune responses. Mycophenolic acid (MPA) is an immunosuppressor commonly used in transplantation, and its effect on DCs has not been fully investigated. METHODS: Monocyte-derived DCs were obtained from healthy volunteers and cultured for 7 days. Cells were...
Topics
- Antigens, CD
- B7-2 Antigen
- CD40 Antigens
- Cell Proliferation
- Cells, Cultured
- Coculture Techniques
- Dendritic Cells
- Humans
- IMP Dehydrogenase
- Immunoglobulins
- Immunosuppressive Agents
- Intercellular Adhesion Molecule-1