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Article

CNI-1493 mediated suppression of dendritic cell activation in vitro and in vivo.

Immunobiology - 1 Jan 2004

Zinser Elisabeth, Turza Nadine, Steinkasserer Alexander

Abstract excerpt

The tetravalent guanylhydrazone CNI-1493 (CNI-1493) has been shown to inhibit macrophage activation, reduce systemic inflammation as well as proinflammatory cytokine production. Here we report for the first time that CNI-1493 also influences the biology of dendritic cells (DC). In order to become potent T cell stimulators of DC have to mature. Interestingly, when CNI-1493 was added to the maturation stimulus the...

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PMID: 15481144
DOI: 10.1016/j.imbio.2004.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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