Article
Immortalized bovine pancreatic duct cells become tumorigenic after transfection with mutant k-ras.
Virchows Archiv : an international journal of pathology - 1 Jun 2001
Löhr M, Müller P, Zauner I, Schmidt C, Trautmann B, Thévenod F, Capellá G, Farré A, Liebe S, Jesenofsky R, Jesnowski R
Abstract excerpt
Mutation of the K-ras gene is thought to be an early and important event in pancreatic carcinogenesis. In order to study the role of this molecular alteration in the transition from the normal to the neoplastic pancreatic cell, bovine pancreatic duct cells were first immortalized by SV40 large T antigen (Ag) complementary (c)DNA transfection and then transfected with a mutated K-ras gene. As did primary duct...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.