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Article

Establishment and characterization of a simian virus 40-immortalized rat pancreatic stellate cell line.

The Tohoku journal of experimental medicine - 1 Sept 2002

Satoh Masahiro, Masamune Atsushi, Sakai Yoshitaka, Kikuta Kazuhiro, Hamada Hirofumi, Shimosegawa Tooru

Abstract excerpt

Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic fibrosis and inflammation. Primary PSCs can be subcultured only several times because of their limited growth potential. A continuous cell line would be valuable in studying molecular mechanisms of these pancreatic disorders. The aim of this study was to establish an immortalized cell line of rat PSCs. PSCs...

Topics

Animals
Antigens, Polyomavirus Transforming
Becaplermin
Blotting, Western
Cell Division
Cell Line
Chemokine CCL2
Culture Media, Serum-Free
Cytoskeleton
Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme-Linked Immunosorbent Assay

Immunohistochemistry

Interleukin-1

Male

Mitogen-Activated Protein Kinases

NF-kappa B

Pancreas

Phenotype

Source

Identifiers

PMID: 12498315
DOI: 10.1620/tjem.198.55

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