Article
Immortalization of normal human salivary gland cells with duct-, myoepithelial-, acinar-, or squamous phenotype by transfection with SV40 ori- mutant deoxyribonucleic acid.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 1993
Azuma M, Tamatani T, Kasai Y, Sato M
Abstract excerpt
BACKGROUND: Based on morphologic and functional differences mainly, 4 distinct types of cells are recognized in human salivary glands. For a better understanding of cellular proliferation and differentiation of human salivary glands as well as carcinogenesis of salivary gland neoplasms, we attempted to establish normal human salivary gland cells in an in vitro system. EXPERIMENTAL DESIGN: Primary cultured human...
Topics
- Animals
- Antigens
- Cell Division
- Cell Line, Transformed
- Cell Separation
- DNA Fingerprinting
- DNA, Viral
- Epitopes
- Humans
- Mice
- Mice, Nude