Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro.

doi:10.1093/carcin/15.11.2461

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Article

Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro.

Carcinogenesis - 1 Nov 1994

Baskaran K, Laconi S, Reddy M K

Abstract excerpt

The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent carcinogen in laboratory animals. In the present study, in vitro transformation of spontaneously immortal hamster pancreatic duct cells following exposure to 20 mM NNK for 1,3,5 and 7 days is describ...

Topics

Animals
Base Sequence
Carcinogens
Cell Transformation, Neoplastic
Cells, Cultured
Cricetinae
Genes, ras
Mesocricetus
Mice
Molecular Sequence Data
Mutation
Nitrosamines
Pancreatic Ducts
Pancreatic Neoplasms

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