Article
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
Cell - 19 Sept 1997
Lam K P, Kühn R, Rajewsky K
Abstract excerpt
Gene targeting experiments have demonstrated that the expression of immunoglobulin heavy chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen receptor (BCR) marks checkpoints in early B cell development that the cells have to pass to survive. To investigate whether the persistence of mature B cells in the peripheral immune system also depends on BCR expression, we have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.