Article
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
Cell - 19 Sept 1997
Lam K P, Kühn R, Rajewsky K
Abstract excerpt
Gene targeting experiments have demonstrated that the expression of immunoglobulin heavy chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen receptor (BCR) marks checkpoints in early B cell development that the cells have to pass to survive. To investigate...
Topics
- Animals
- Antigens, Surface
- Apoptosis
- B-Lymphocytes
- Cell Differentiation
- Female
- Flow Cytometry
- Gene Deletion
- Gene Expression Regulation, Developmental
- Gene Targeting
- Hematopoietic Stem Cells
- Immunoglobulin Heavy Chains
- Integrases
- Male
- Mice
- Mice, Transgenic
- Oncogene Proteins
- Phenotype