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Article

B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.

The Journal of experimental medicine - 16 Aug 1999

Lam K P, Rajewsky K

Abstract excerpt

Mice expressing the immunoglobulin (Ig) heavy (H) chain variable (V) region from a rearranged V(H)12 gene inserted into the IgH locus generate predominantly B-1 cells, whereas expression of two other V(H) region transgenes (V(H)B1-8 and V(H)glD42) leads to the almost exclusive generation of conventional, or B-2, cells. To determine the developmental potential of B cells bearing two distinct B cell antigen...

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Identifiers

PMID: 10449518
DOI: 10.1084/jem.190.4.471
PMCID: PMC2195595

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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