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Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

27 Mar 2023

Abstract excerpt

Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstrating full B-cell development competence. Comparison of the naïve B-cell receptor (BCR) repertoires of Kymice BCRs, naïve human, and murine BCR repertoires revealed...

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PMID: 36971345
DOI: 10.7554/elife.81629

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