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Article

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

2022-06-29

Abstract excerpt

Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect® Transgenic mouse (Kymouse) demonstrating full B-cell development competence. Comparison of the naïve B-cell receptor (BCR) repertoires of Kymice BCRs naïve human and murine BCR repertoires revealed key...

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Identifiers and source

Literature Corpus work
60742bc5-5ccf-514f-bb95-473cc26d1632
DOI
10.1101/2022.06.27.497709
Open publication

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Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencingDOI 10.1101/2022.06.27.497709
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