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Article

Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12.

Journal of autoimmunity - 1 Apr 2015

Collin Roxanne, Dugas Véronique, Chabot-Roy Geneviève, Salem David, Zahn Astrid, Di Noia Javier M, Rauch Joyce, Lesage Sylvie

Abstract excerpt

Autoimmune diseases result from a break in immune tolerance leading to an attack on self-antigens. Autoantibody levels serve as a predictive tool for the early diagnosis of many autoimmune diseases, including type 1 diabetes. We find that a genetic locus on mouse chromosome 12 influences the affinity maturation of antibodies as well as autoantibody production. Thus, we generated a NOD.H2(k) congenic strain...

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Identifiers

PMID: 25623266
DOI: 10.1016/j.jaut.2015.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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