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Article

mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation.

The Journal of biological chemistry - 7 Sept 2001

Belcheva M M, Szùcs M, Wang D, Sadee W, Coscia C J

Abstract excerpt

Phosphorylation of the MAPK isoform ERK by G protein-coupled receptors involves multiple signaling pathways. One of these pathways entails growth factor receptor transactivation followed by ERK activation. This study demonstrates that a similar signaling pathway is used by the mu-opioid receptor (MOR) expressed in HEK293 cells and involves calmodulin (CaM). Stimulation of MOR resulted in both epidermal growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11457825
DOI: 10.1074/jbc.M101535200

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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