Epiregulin and EGFR interactions are involved in pain processing.

doi:10.1172/JCI87406

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Article

Epiregulin and EGFR interactions are involved in pain processing.

The Journal of clinical investigation - 1 Sept 2017

Martin Loren J, Smith Shad B, Khoutorsky Arkady, Magnussen Claire A, Samoshkin Alexander, Sorge Robert E, Cho Chulmin, Yosefpour Noosha, Sivaselvachandran Sivaani, Tohyama Sarasa, Cole Tiffany, Khuong Thang M, Mir Ellen, Gibson Dustin G, Wieskopf Jeffrey S, Sotocinal Susana G, Austin Jean Sebastien, Meloto Carolina B, Gitt Joseph H, Gkogkas Christos, Sonenberg Nahum, Greenspan Joel D, Fillingim Roger B, Ohrbach Richard, Slade Gary D, Knott Charles, Dubner Ronald, Nackley Andrea G, Ribeiro-da-Silva Alfredo, Neely G Gregory, Maixner William, Zaykin Dmitri V, Mogil Jeffrey S, Diatchenko Luda

Abstract excerpt

The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth, proliferation, and tissue regeneration. In the present study, we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG), in pain processing. We show that inhibition of EGFR with clinically available compounds strongly reduced nocifensive...

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Identifiers

PMID: 28783046
DOI: 10.1172/JCI87406
PMCID: PMC5669538

Genes

EGFR
EREG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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