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Article

Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells.

FEBS letters - 13 Feb 2004

Li Hongbing, Ruano María José, Villalobo Antonio

Abstract excerpt

We have previously shown that exogenous calmodulin (CaM) binds to the epidermal growth factor receptor (EGFR) at its cytosolic juxtamembrane region inhibiting its tyrosine kinase activity. We demonstrate in this report that endogenous CaM binds to EGFR in intact cells as CaM co-immunoprecipitates with EGF-activated and non-activated receptors. We also show in living cells that cell-permeable CaM inhibitors...

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Source

Identifiers

PMID: 14960328
DOI: 10.1016/S0014-5793(04)00067-5

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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