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Article

EGFR signal transactivation in cancer cells

1 Dec 2003

Abstract excerpt

The EGFR (epidermal growth factor receptor) plays a key role in the regulation of essential normal cellular processes and in the pathophysiology of hyperproliferative diseases such as cancer. Recent investigations have demonstrated that GPCRs (G-protein-coupled receptors) are able to utilize the EGFR as a downstream signalling partner in the generation of mitogenic signals. This cross-talk mechanism combines the...

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PMID: 14641026
DOI: 10.1042/bst0311203

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