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Article

Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jan 2009

Yu Y Joy, Arttamangkul Seksiri, Evans Christopher J, Williams John T, von Zastrow Mark

Abstract excerpt

mu-Opioid receptors (MORs) are G-protein-coupled receptors (GPCRs) that mediate the physiological effects of endogenous opioid neuropeptides and opiate drugs such as morphine. MORs are coexpressed with neurokinin 1 receptors (NK1Rs) in several regions of the CNS that control opioid dependence and reward. NK1R activation affects opioid reward specifically, however, and the cellular basis for this specificity is...

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Identifiers

PMID: 19129399
DOI: 10.1523/JNEUROSCI.4315-08.2009
PMCID: PMC2775560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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