Article
Interplay between termination and translation machinery in eukaryotic selenoprotein synthesis.
Journal of molecular biology - 20 Jul 2001
Grundner-Culemann E, Martin G W, Tujebajeva R, Harney J W, Berry M J
Abstract excerpt
Termination of translation in eukaryotes is catalyzed by eRF1, the stop codon recognition factor, and eRF3, an eRF1 and ribosome-dependent GTPase. In selenoprotein mRNAs, UGA codons, which typically specify termination, serve an alternate function as sense codons. Selenocysteine incorporation involves a unique tRNA with an anticodon complementary to UGA, a unique elongation factor specific for this tRNA, and...
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